MetaboliSim

Energy System Contribution Over Time

Description

This plot shows the relative contribution of the three energy systems (oxidative, glycolytic, and PCr) to overall ATP turnover.

Oxidation and Glycolysis Characteristics

Show variables:

ATP PCr VO₂ss vLa

Initial Values

ATP + ADP + AMP (S_A)

PCr + Pi (S_C)

CHEP Equilibrium

M2 (×10⁹)

Oxidative Activation

ks1

nox

Glycolysis

ks2

ks3

n_H

VLamax (mmol/L/s)

pH Range

Start

End

Step

Editable Parameters

[PCr] (mmol/kg)

[La]blood (mmol/l)

VO₂ (ml/min/kg body)

Simulation Settings

Time step (s)

Complete Initial State

Constants
Descriptions

Thermodynamics

R [kJ/(mol·K)]

T [K]

ΔG₀ [kJ/mol]

Phosphate Pools

S_A [mmol/kg]

S_C [mmol/kg]

CHEP Equilibrium

Oxidative Phosphorylation

ks1 [(mmol/kg)²]

nox

kVO2 [1/s]

bVO2 [mmol ATP/(ml O2)]

Glycolysis

ks2 [(mmol/kg)²]

ks3

n_H

bVLa [mmol ATP/mmol La]

Lactate Resynthesis

VLares_max [mmol/L/min]

KADP1 [mmol/kg]

KVLares [mmol/L]

bVLares [mmol ATP/mmol La]

Lactate Kinetics

K_dif

K1_exp

KLaO2

K_el_ox

Vol_rel

muscle_water_factor

Buffering & Thresholds

d_buff [mmol/(kg·pH)]

pH_base

ATP_exhaustion [mmol/kg]

pH_exhaustion

PCr_exhaustion [mmol/kg]

ATP Demand Mapping

Ks4

ATP_rest [mmol/(kg·s)]

Apply or Reset Constants

Scientific Descriptions of Model Constants

Steady-State

Oxidation and Glycolysis Characteristics

Simulation Settings